Custom-Made Quorum Sensing for a Eukaryote

Tailor-made LasR agonists modulate quorum sensing in Pseudomonas aeruginosa.

The primary quorum sensing system in the opportunistic pathogen Pseudomonas aeruginosa is regulated through the synthesis and secretion of N-3-oxo-dodecanoyl-L-homoserine lactone (C12) which binds the transcriptional activator LasR. In this study we report the design, synthesis and biological evaluation of new analogs of C12. Analysis of the autoinducer binding site cavity of LasR revealed a po...

A custom-made head pointer for children.

Severely physically disabled adults and children may be able to use a head pointer to access an augmentative communication system or to participate in activities. This paper describes how to make and fit a thermoplastic head pointer and how to train a child to use it.

Quorum Sensing in Microbial Virulence

Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...

Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals.

Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryotic host, the model legume Medicago truncatula, is able to detect nanomolar to m...

Custom Made Mold Brachytherapy